Research Profile of Dr. Christopher Larbie


Dr. Christopher Larbie is a Biochemist, with interest in Medicinal and Natural Product Pharmacology, Dr. Larbie’s research work has focused on the use of plant extracts (weeds and ornamental plants) for the management of cancer, organ specific diseases (kidney and liver) and metabolic syndrome (diabetes and dyslipidaemia). With emergency of personalized therapy, his other research areas have focused on population genetic variations in cytochrome P450 enzyme system and autoimmune diseases and nutrigenetics of diabetes. As a lecturer, Dr. Larbie lectures in Metabolism in Health and Diseases, Food Biochemistry, Biological Chemistry, Bioethics and Biosafety and Functional Foods and Nutraceuticals.

“My research work on Ageratum conyzoides has resulted in the characterization of a novel flavone (8-chloro-5-hydroxy-2-(4-hydroxy-3, 5-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one) currently under further development into an alternative anticancer therapy”.

Dr. Larbie is a member of the following international research associations: Society for Medicinal Plants and Natural Product, West African Society for Pharmacology, and Ghana Biomedical Convention.

Qualification

  • Certificate: Cancer in the 21st Century: The Genomic revolution (Online course)
  • Doctor of Philosophy (Ph.D.) in Biochemistry - 2013.
  • Bachelor of Science (B.Sc.) in Biochemistry - 2006

Research Areas

Specific areas of research interest include:

  • Use of plant extracts (weeds and ornamental plants) for the management of cancer,) Food Rheology (rheological characterization of food biopolymers i.e., polysaccharide-protein systems)
  • Population genetic variations in cytochrome P450 enzyme system
  • Autoimmune diseases and nutrigenetics of diabetes.

Institutions Attended

  • 2007 - 2013 Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
  • 2002 - 2006 Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana. (BSc. (Hons) Biochemistry).
  • 1998-2000: Ghana Secondary Technical School.

Research Output

Publications

  1. Anim, M.T., Larbie, C., Appiah-Opong, R., Tuffour, I., Owusu, K.B.A. and Aning, A. (2016). Phytochemical, antioxidant and cytotoxicity of hydroethanolic extract of Crotolaria retusa L. WJPR, 5(2), 162-179.
  2. Apprey, C., Larbie, C., Arthur, F.K.N., Appiah-Opong, R., Annan, R.A. and Tuffour, I. (2015). Antiproliferative effects if isoflavones from soybean and soymilk powder on lymphoma (DG 75) and leukemia (CEM) cell lines. British Journal of Pharmaceutical Research, 7(3), 206-216.
  3. Acheampong, F., Larbie, C., Arthur, F.K.N., Appiah-Opong, R. and Tuffour, I. (2015). Antioxidant and anticancer properties of Ageratum cornyzoides aqueous extracts. Journal of Global Biosciences, 4(SI 1), 1804-1815.
  4. Acheampong, F., Larbie, C., Appiah-Opong, R., Arthur, F.K.N. and Tuffour, I. (2015). In vitro antioxidant and anticancer properties of hydroethanolic extracts and fractions of Ageratum cornyzoides. EJMP, 7(4), 204-215.
  5. Larbie, C., Appiah-Opong, R., Acheampong, F., Tuffour, I., Uto, T., Agyare-Yeboah, G., Abboah-Offei, O., Tagoe, D.N.K., and Inkabi, S.E. (2015). Anti-proliferative effect of Ficus pumila Linn. on human leukemic cell lines. IJBPS, 4(2): 330-336.
  6. Apprey, C., Larbie, C., Annan, R.A., Arthur, F.K.N., Abdulai-Saiku, S., Berkoh, D. amd Osei-Akoto, A. (2015). Effect of chemotherapy and disease burden on the nutritional status of patients undergoing treatment for Burkitt’s lymphoma. Der Pharmacia Lettre, 7(2): 95-99.
  7. Larbie, C., Appiah-Opong, R., Acheampong, F., Tuffour, I., Uto, T., Torkornoo, D., Marfo, E., Ankamah-Mensah, D., Opoku Mensah, E. and Abotsi, P. (2015). Anti-proliferative effect of Amaranthus viridis Linn. on human leukemic cell lines – a preliminary study. IJBPS, 6(3): 236-243.
  8. Larbie, C., Torkornoo, D. and Dadson, J. (2014). Anti-Diabetic and hypolipidaemic effect of eotanicals: a review of medicinal weeds on KNUST campus, Kumasi. J App Pharm Sci; 4 (10): 097-104.
  9. Larbie, C., Acquah, S.J., Van-Ess, J., and Dadson, J. (2014). Heavy metal contamination of cabbage sections from different farms in Ghana. Annals of Biological Research, 5 (8): 18-23.
  10. Arthur, F.K.N., Dadson, J.K., Yeboah-Awudzi, M. and Larbie, C. (2014). Body mass index and its effects on the rate of hospital visits of staff of the Kwame Nkrumah University of Science and Technology, Kumasi. Archives of Applied Science Research, 6(4): 198-202.
  11. Larbie, C. and Abboah-Offei, O. (2014). Anticancer properties of some ornamental plants on KNUST campus, Kumasi. Journal of Phytopharmacology, 5(5): 366-370. 
  12. Larbie, C. and Ankama Mensah, D. (2014). Botanical for managing cardiovascular disorders; a review of medicinal weeds on KNUST campus. GJMRI; 3(9): 349-358.
  13. Arthur, F.K.N., Woode, E., Terlabi, E.O., and Larbie, C. (2012). Bilirubin lowering potential of Annona muricata in temporary jaundiced rats. American Journal of Pharmacology and Toxicology: 7 (2); 33 – 40.
  14. Arthur, F.K.N., Woode, E., Terlabi, E.O., and Larbie, C. (2012). Evaluation of hepatoprotective effect of aqueous extract of Annona muricata (Linn.) leaf against carbon tetrachloride and acetaminophen induced liver damage. Journal of Natural Pharmaceuticals: 3 (1); 25 – 30. 
  15. Arthur, F.K.N., Woode, E., Terlabi, E.O., and Larbie, C. (2011). Evaluation of acute and subchronic toxicity of Annona muricata (Linn.) aqueous extract in animals. European Journal of Experimental Biology: 1 (4); 115 – 124.
  16. Mensah, F.O., Twumasi, P., Amenawonyo, X.K., Larbie, C., and Baffo, A.K. (2010). Pica practice among pregnant women in Kumasi metropolis of Ghana. International Health: 2 (4); 282 -286.
  17. Oduro, I., Larbie, C., Amoako, T.N.E., and Antwi-Boasiako, A.E. (2009). Proximate composition and basic phytochemical assessment of two common varieties of Terminalia catappa. Journal of Science and Technology: 29 (2); 1 – 6.
  18. Larbie, C., Oduro, I., Amankwah-Addoh, E., Akyiaa, C., Manu, F., Asiedu, M., and Inkoom, R., (2008). Assessing stress levels in students of the College of Science, KNUST, Kumasi-Ghana. Rapporteur Report of the 2nd College of Science Biennial Research Conference. pp 108 – 116.

Ongoing Research

  1. Isolation and characterization of compounds including a novel flavone from Ageratum conyzoides demonstrates promising apoptosis induction in Jurkat cells (Submitted – Planta Medica)
  2. Extracts of Codiaeum variegatum (l.) A. Juss is cytotoxic on human leukemic, breast, liver and prostate cancer cell lines (Submitted – BMC Complementary and Alternative Medicine)
  3. Prevalence of the genetic mutation CYP2C8*5 in selected ethnic groups in southern Ghana
  4. Acute and sub-chronic toxicity of aqueous ethanolic extract of Ficus pumila leaves in rats
  5. Evaluation of the hepatoprotective effect of Ficus pumila hydroethanolic Extract on CCl4-induced liver damage in rats
  6. Antioxidant Micronutrient Status and Pregnancy Outcomes in Ghanaian Adolescents attending Antenatal Clinic in Urban (Suntreso) and Rural (Mampong) Hospitals (Submitted – European Journal of Nutrition and Food Safety)
  7. Genetic profile of patients with autoimmune neurodegenerative diseases
  8. Retrospective effects of diet on glucose metabilizing gene products in type 2 diabetics

Websites:

http://biochemistry.knust.edu.gh/StaffDirectory/academic-staff/drchristopherlarbiehttps://www.researchgate.net/profile/Christopher_Larbiehttps://scholar.google.com/citations?user=SQ_wLT0AAAAJ&hl=en

Contact

Department of Biochemistry and Biotechnology
KNUST - Kumasi
Cell Number - +233-24304450961
Email address - ekowlarbie@gmail.com or clarbie.cos@knust.edu.gh

 


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